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KMID : 0388220120190040216
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Journal of the Korean Rheumatism Association
2012 Volume.19 No. 4 p.216 ~ p.219
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A Case of Development of Vitiligo Followed by TNF-? Antagonist Treatment for Rheumatoid Arthritis
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Song Ran
Kim So-Mi
Lee Sang-Hoon
Lee Yeon-Ah
Hong Seung-Jae
Cho Hee-Ryung
Kim Gou-Young
Yang Hyung-In
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Abstract
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As the usage of biologics for rheumatic diseases increases, such as rheumatoid arthritis and ankylosing spondylitis, various cutaneous adverse events are also being increasingly reported. We experienced a case of development of vitiligo during a TNF-? antagonist therapy in a 22-year- old woman with rheumatoid arthritis. The patient was presented with vitiligo lesions on the dorsum of both hands after 1 month of treatment with etanercept. Vitiligo improved with topical tacrolimus ointment and excimer laser treatment without the discontinuation of etanercept. No clearly defined mechanism for vitiligo induced by TNF-? antagonist exits. However, considering that vitiligo is an autoimmune disorder, the development of this skin lesion in association with the TNF-? antagonist could be explained by a paradoxical induction of the autoimmune process.
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KEYWORD
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Rheumatoid arthritis, TNF-? antagonist, Vitiligo
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